Abstract
The periaqueductal gray (PAG) region of the midbrain has been implicated in both stimulation-produced and opioid-induced analgesia. High-affinity μu-selective opioid-binding sites associated with μu type opioid receptors have been detected in rat PAG-enriched P 2, membranes, and these receptors have been shown to be coupled to guanine nucleotidebinding proteins (G-proteins). In the present study the potential G-protein-mediated coupling of μu type opioid receptors to the inhibition of adenylyl cyclase was examined utilizing in vitro adenylyl cyclase assays. In the presence of Na +, opioid agonists inhibited adenylyl cyclase in aμu selective, naloxone reversible, dose dependent, and pertussis toxin sensitive manner. Overall the data suggests that μu type opioid receptors in the rat PAG are coupled to G-protein-mediated inhibition of adenylyl cyclase.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
