Abstract
Coenzyme Q10 is a natural antioxidant of the oil-soluble benzoquinone group involved in the transport of electrons in mitochondria. Q10 possesses a broad spectrum of pharmacological activity. However, the insolubility in water and low bioavailability upon peroral administration are significant disadvantages of this coenzyme. The present work was aimed at biopharmaceutical evaluation of nanosystems (NS) with coenzyme Q10 suitable for peroral administration, which exhibit increased bioavailability in vitro. Solid NS of coenzyme Q10 with polyethylene glycol (PEG) of various molecular weights (1500, 6000, 35000) were prepared. The sizes of particles were within 48.4 - 200.3 nm. The influence of PEG molecular weight and ratio of components in the NS dispersion was evaluated by means of dispersion analysis. A regression equation describing the effect of these factors on the drug release and dissolution rate was obtained. The response surfaces that adequately describe the drug dissolution were plotted.
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