Abstract
Two new α-pyrone derivatives, fusaripyrones C and D (1 and 2), along with six known compounds, namely phomapyrone C (3), fusarilactone A (4), pleospyrone D (5), 5-hydroxy-7-(2′-hydroxypropyl)-2-methyl-chromone (6), phenylacetic acid (7), and p-hydroxyphenylacetic acid (8) were isolated from Fusarium sp. L33, an endophytic fungus isolated from the leaves of Dioscorea opposita. Their structures were elucidated by NMR spectra, HRESIMS, optical rotation experiments and single-crystal X-ray diffraction analysis. Compounds 2, 3, and 6 were evaluated for their cytotoxic activity against five selected human tumor cell lines.
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