Abstract
Pleurotus nebrodensis have been used as a traditional remedy and a food source. Our study focuses on figuring out the possibility of Pleurotus nebrodensis as cosmetic materials. We examined anti-oxidant, anti-wrinkle, anti-inflammation and whitening effects. The SOD-like activity was 69.7 ± 2.31 at 125 ㎍/mL, compared to the standard sample L-ascorbic acid 1 mM 34.7 ± 0.79. It was 11.5 ± 0.27 ㎎/g Naringin base and 64 ± 1.45 GAE (Gallic acid) base as a measurement result of total flavonoid and total polyphenol contents. GME showed 24.5% (L-tyrosine), 16.6% (L-DOPA) of tyrosinase inhibition assay, respectively. In elastase inhibition assay showed 36.2% of inhibition at a concentrations 200 ㎍/mL, tyrosinase and elastase activation were found to inhibited dose-dependent. As a result of measuring the collagen precursor pro-collagen type 1, the amount of collagen synthesis was 434 ng/mL at a concentration of 500 ㎍/mL. The higher the concentration of GME the greater the wrinkle reduction and whitening effects. Anti-inflammatory activites measured nitric oxide (NO) and cell viability in LPS-induced macrophage RAW264.7 cell, it was found to inhibit NO production in a concentration-dependent manner. These results suggest methanol extracted Pleurotus nebrodensis has excellent activities in the anti-wrinkle, anti-inflammation and whitening. Therefore, Giant mushroom Pleurotus nebrodensis may have value as the potential cosmetic formulations.
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