ЭФФЕКТИВНОСТЬ ЛЕЧЕНИЯ БОЛЬНЫХ ТУБЕРКУЛЕЗОМ ЛЕГКИХ С ПРЕ-ШЛУ И ШЛУ M. tuberculosis C ИСПОЛЬЗОВАНИЕМ РАЗЛИЧНЫХ СПОСОБОВ ВВЕДЕНИЯ ПРОТИВОТУБЕРКУЛЕЗНЫХ ПРЕПАРАТОВ

Abstract

Aim: to evaluate effectiveness of treatment of patients with extensively drug resistant (XDR) or pre-extensively drug resistant (pre-XDR) pulmonary TB using parenteral administration of TB drugs. Materials and methods. We carried out a prospective open cohort study of 143 patients with pulmonary TB hospitalized in 2022. The patients were divided into two groups according to the route of drug administration. The main group consisted of 74 patients, who received parenteral TB drugs before sputum conversion followed by oral drug administration. Parenteral drug administration was indicated to patients with severe intoxication syndrome, advanced TB process, or concomitant gastrointestinal diseases. The control group consisted of 69 patients, who received all TB drugs orally. Oral drug administration was also indicated to patients with difficult venous access. Results. Sputum conversion was observed by the third month of treatment much faster in the main group than in the control group. Treatment effectiveness by cavity closure did not differ between the groups. Conclusion. Intravenous administration of TB drugs contributes to rapid sputum conversion, which allows earlier patient discharge from hospital or surgical treatment.