Abstract
This article was prepared in response to increasing difficulties encountered by phthisiologists in the diagnostics of TB or latent TB infection (LTI) using immunological methods. The author with over 50-year experience in the immunology of infection tried to explain the causes of negative results of different immunological reactions (skin, serological, or cellular immunity reactions) based on his own experience and literature data. Errors in the interpretation of specific tests due objective reasons associated with genetic traits of a microorganism were described. A complex approach to both choice of immunological tests and use of different antigenic stimuli was recommended to increase the accuracy of immunodiagnostics results.
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