Abstract
An electrophysiological study was made with rabbits on the electrical changes of photopalpebral reflex (PPR) which were cumulatively recorded by computer. In addition, electroretinogram (ERG), visual evoked response (VER) and photo-evoked eyelid microvibrat ion (MV) were simultaneously recorded.The results o btained were as follows.1.9 components (PPR1, PPR2, PPR3, PPR4, PPR5, PPR8, PPR7, PPR8 and PPR9) were observed in PPR with monopolar lead. In ERG, there were found a wave and 3 oscillating potentials (O1,O2 and O3) on b wave, and 5 components (VER1, VER2, VER3, VER4and VER5) were shown in VER.2. All components of PPR and ERG disappeared when the intraocular pressure was elevated as high as 120-160 mmHg.3. The componen ts of PPR5-9 and VER disappeared after the optic nerve was cut off.4. The components of PPR5-9 disappeared after the brain stem reticular formation (RF) was destroyed.5. All components of PPR showed no appreciable change with 3Hz stimulation on RF, whereas all but PPR1 increased in amplitude with 100Hz stimulation on RF.6. The PPR5-9 increased in amplitude and the PPR6,7,8 de creased after the destruction of the nucleus ventralis anterior (VA).7. The PPR5-9 decreased in amplitude with 3Hz stimulation on VA, but they increased with 100Hz stimulation.8. W hen PPR and MV were recorded simultaneously, MV was found coincidental with the culmination of PPR5-8.9. The ampli tude of PPR5-8 decreased after either the removal of M. orbicularis oculi or the resection of external eye muscles, and they disappeared after the simultaneous resection of both muscles.10. The amplitude of PPR5-9 decreased after the amputation of n. facialis and they disappe ared following additional retrobulbar anesthesia.11. Inhibitory effect was observed on the amplitude of PPR6-8, following the administration of gallamine.12. Barbiturate, chlorpromazine, diazepam and tofranil had inhibitory effect predominantly on all the components of PPR. Whereas cardiazol, when properly given, showed facilitatory effect on PPR5-9. Amphetamine and CDP-choline showed no noticeable effect.13. ERG was not affected significantly with the administration of such chemicals as barbiturate, chlorpromazine, diazepam, tofranil, cardiazol, amphetamine and CDP-choline.14. VER was not affected either with the administration as cardiazol, amphetamine or CDPcholine.15.9 components of PPR were also found in men as well as in rabbits. When a series of photic stimulation was given through one eye and led out of the other shielded eye, the components of PPR1-4 and ERG disappeared, but the PPR5-9 and MV were also recorded. On giving mathematical questions, the amplitude of PPR5-9 and MV increased.Consequently, it was obvious that the early components of PPR (PPR1-4) were closely related to ERG, that the late components of PPR (PPR5-9) had their origin in the central nervous system (especially in RF), that, above all, the components of PPR5-8 were parallel with MV and that the PPR9 was a potential different from MV as well as the secondary response of VER and activated by nervous activities higher than consciousness.
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