Abstract
Background. Obstructive sleep apnea/hypopnea syndrome (OSAHS) seems to have negative effect on the state of patients with gastroesophageal reflux disease (GERD).Aim: to evaluate plasma levels of type IV collagen as a potential biomarker of esophageal mucosa damage in patients with GERD accompanied by OSAHS.Material and methods. A total of 120 patients were examined: 29 persons with GERD, 35 – with GERD and OSAHS, 30 – with OSAHS, 26 persons – the comparison group. Respiratory monitoring and esophagogastroduodenoscopy were performed. Plasma level of type IV collagen was evaluated in 80 patients by using enzyme-linked immunosorbent assay.Results. Patients with erosive esophagitis had higher plasma levels of type IV collagen then patients with nonerosive esophagitis and those of the comparison group. Patients with GERD accompanied by OSAHS had higher plasma levels of type IV collagen in comparison with those who had GERD without OSAHS.Conclusions. OSAHS has negative impact on the state of esophageal mucosa in patients with GERD which leads to an increase in type IV collagen concentration in plasma.
Highlights
Obstructive sleep apnea/hypopnea syndrome (OSAHS) seems to have negative effect on the state of patients with gastroesophageal reflux disease (GERD)
HIF-1α contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression / S
The study was approved by the local ethics committee
Summary
Advances in the physiological assessment and diagnosis of GERD / E. Д. Диагностика синдрома обструктивного апноэ сна в условиях общесоматического стационара /. М. Анализ трех и более независимых групп количественных данных / А. HIF-1α contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression / S. Hypoxia suppresses E-cadherin and enhances matrix metalloproteinase-2 expression favoring esophageal carcinoma migration and invasion via hypoxia inducible factor-1 alpha activation / S. Dynamic Reorganization and Enzymatic Remodeling of Type IV Collagen at Cell-Biomaterial Interface.
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