Abstract
Наведений огляд літератури дозволив ознайомитися з перспективним напрямком сучасної медицини, а саме — ДНК-дослiдженнями полiморфних генiв. Виявлення структури генів, що кодують білкові молекули, а також впровадження в рутинну лабораторну практику нових діагностичних технологій зробили можливим тестування різних генних поліморфізмів, що дозволяє передбачати ризики розвитку певних захворювань у конкретного індивіда. Зокрема, генетичне тестування дозволяє з’ясувати, чи є спадкова схильність до розвитку алергічної патології, а саме — бронхiальної астми, алергiчного ринiту або атопiчного дерматиту.
Highlights
There is a lot of data about the pathology associated with defects in Toll-like receptor system [1]
In recent years, accumulating more information about the pathology related to defects in the system of Toll-4 receptor SIMILAR Based on the results, 96.85% of healthy subjects determined the normal genotype TLR4 (AA) and two mutant - the frequency of heterozygotes (AG ) was 2.1% homozygotes (GG) – 1.05%, while in children with atopic asthma (BA), the frequency of the mutant heterozygous and homozygous genotypes at 5.39 and 1.79 times respectively higher than the control parameters [2,8,9]
For the results of modern scientific research, it is proved that the development of asthma in children, affect polimorphisms in the proteasome mturtion protein gene (POMP), filaggrin gene (FLG), mammalian target of rapamycin gene (MTOR), autophagy gene (ATG5) [5]
Summary
There is a lot of data about the pathology associated with defects in Toll-like receptor system [1]. In recent years, accumulating more information about the pathology related to defects in the system of Toll-4 receptor SIMILAR Based on the results, 96.85% of healthy subjects determined the normal genotype TLR4 (AA) and two mutant - the frequency of heterozygotes (AG ) was 2.1% homozygotes (GG) – 1.05%, while in children with atopic asthma (BA), the frequency of the mutant heterozygous and homozygous genotypes at 5.39 and 1.79 times respectively higher than the control parameters [2,8,9].
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