Abstract
<p class="p1"><span class="s1">With the purpose of increasing of the ef ciency of the combination treatment of in ammatory periodontal diseases in patients with Helicobacter pylori-associated gastroduodenal pathologies a new spot-on pharmaceutical composition based on organosilicone glycerol hydrogel («Silativit») with the addition of speci c against Helicobacter pylori active additives bismuthate tripotassium dicitrate was developed. The results of the new pharmaceutical compositions animals tests prove its safety for the clinic use. The results of randomized clinical studies have shown the new pharmaceutical composition in combination with the local application of bicarbonate mineral waters and synbiotic to be effective for the treatment of periodontal disease in such patients. The comparative analysis of the data obtained prove the use of a the new pharmaceutical compositions in combination with local application of mineral waters and synbiotic to be more effective than the traditional periodontitis combination therapy thanks to the reduction of the period of this disease exacerbations treatment, absence of progression and a stable remission of periodontitis. </span></p>
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