Клінічний перебіг вагітності, пологів та стан плаценти в жінок із HCV-інфекцією

Abstract

Purpose - to conduct a prospective clinical and statistical analysis of the course of pregnancy, childbirth and placental condition in women with hepatitis C virus (HCV-infection). Materials and methods. A prospective clinical and laboratory study of the course of pregnancy, childbirth and placental condition in 40 pregnant women with HCV infection (the main group - MG) was conducted on the basis of the Kyiv City Centre for Reproductive and Perinatal Medicine for the period 2020-2022. 50 healthy pregnant women formed the control group (CG). Statistical processing of the study results was performed using standard software Microsoft Excel 5.0 and Statistica 8.0. Results. The course of pregnancy in women of MG in the trimester I was 2 times more often complicated by early toxicosis compared with women of CG - 3 (7.5%) vs. 2 (4.0%) cases, respectively; p>0.05. The threat of pregnancy termination was 4.3 times more frequent in pregnant women of MG compared with women of CG - 7 (17.5%) vs. 2 (4.0%) cases, respectively; p<0.001. Gestational anemia occurred in 1/3 of pregnant women of MG, which was significantly higher than in pregnant women of CG - 12 (30.0%) vs. 6 (12.0%) cases, respectively; p<0.001. Pregnancy edema (mainly in the trimester III) was detected in pregnant women of MG 4.3 times more often than in pregnant women of CG - 13 (32.5%) vs. 4 (8.0%) cases, respectively; p<0.001. Conclusions. Pregnant women with HCV infection are characterized by a significant increase in the following complications, in particular, during pregnancy: threat of abortion, threat of preterm birth, gestational anemia, placental dysfunction, fetal growth retardation syndrome, preeclampsia; during labor: premature and prenatal amniotic fluid discharge, preterm birth, weakness of labor activity. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patients was obtained for conducting the studies. No conflict of interests was declared by the author.