γ‐Fe2O3@HAp@PBABMD@Cu magnetic nanoparticles: Efficient, green, and recyclable novel nanocatalyst for the synthesis of densely functionalized pyrrole‐pyrido[2,3‐d]pyrimidine hybrids

Abstract

AbstractA green heterogeneous nanocatalyst, Cu(II)‐PBABMD complex immobilized on core‐shell magnetic γ‐Fe2O3@HAp, was successfully designed, synthesized, and characterized by FTIR, XRD, FESEM, EDX, VSM, TGA, BET, ICP‐OES, and TEM techniques. The magnetic Cu(II) nanocatalyst was employed as a novel, ecofriendly, recyclable, and safe catalyst for the one‐pot, three‐component condensation of 6‐amino‐2‐thioxo‐2,3‐dihydropyrimidin‐4(1H)‐one, 3‐(1‐methyl‐1H‐pyrrol‐2‐yl)‐3‐oxopropanenitrile and aromatic aldehydes to produce new pyrido[2,3‐d]pyrimidine derivatives, in refluxing EtOH with excellent yield (90–97%) and short reaction time (8–13 min). The nanocatalyst was used and recycled in eight runs without significant leaching or loss of its catalytic activity.