Abstract
Lipotropin, β-endorphin and a series of peptides related to β-endorphin were extracted from rat antrum and resolved by gel filtration, ion exchange chromatography and high pressure liquid chromatography; the concentrations of the peptides were determined by radioimmunoassay. The major peptide with β-endorphin immunoreactivity present in the antrum was lipotropin but it was accompanied by substantial quantities of β-endorphin in its biologically active form; in addition there were minor quantities of a number of inactive β-endorphin related peptides. The experiments demonstrate that in rat antrum gastrin can be accompanied by both active and inactive forms of β-endorphin. The implications of post-translational processing mechanisms common to gastrin and β-endorphin are discussed.
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