Abstract
As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).
Highlights
To improve the health of the population, a variety of antimicrobial agents have been used to suppress and kill harmful microorganisms in people’s living environments [1,2,3]
Appear at 1354 and 1137 cm−1, respectively. This is in good agreement with literature data
In the spectrum of pure PR, the broad band at 3356 cm−1 and the weak band at 1643 cm−1 were assigned to the stretching vibration of the hydroxyl groups in α-CD and the hydration of water, respectively, which is similar to that of pseudo-PR between poly(ethylene glycol) (PEG) and α-CD [25]
Summary
To improve the health of the population, a variety of antimicrobial agents have been used to suppress and kill harmful microorganisms in people’s living environments [1,2,3]. The research on broad-spectrum antibacterial materials showing nontoxicity and bio-heat resistance has become extremely urgent [5,6,7]. Compared to other kinds of antibacterial agents, silver-based antimicrobial materials are effective and safe. They have been widely used and have become a focus of commercialization in antimicrobial research [8,9]. Silver sulfadiazine (SD-Ag) has received wide-spread acceptance as a topical agent to control bacterial infections [10]. The key of bacteriostatic agents is silver ions [11], which significantly affect the treatment of burn wounds and the promotion of wound healing and infection control. Crystalline silver sulfadiazine deteriorates under the influence of light or heat
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