Abstract

Objective To prepare epirubicin-loaded chitosan nanoparticles (PEG/CS-EPI NP)modified by polyethylene glycol and study the drug release behavior in vitro. Methods PEG/CS-EPI NP were prepared by ionic gelation technique. The particle size and morphology were determined by laser scattering and transmission electron microscopy respectively. The drug loading and releasing behavior of PEG/CS-EPI NP in vitro were examined by ultraviolet spectrophotometry and dynamic dialysis. Results NPs were round or ovoid spheres,evenly distributing,with a mean diameter of (322.1 ± 14.4) nm. The loading capacity and encapsulation efficiency were estimated to be ( 13.9 ± 1.1 )% and (74.2 ± 1.8)%,respectively. The 72 h cumulative release was (82.0±2.1)% of the loaded dose. Conclusion Spherical and well distributed PEG/CS NP with high encapsulation efficiency and good performance of sustained drug release can be prepared by ionic gelation technique. Key words: Epirubicin; Chitosan; Nanoparticles; Polyethylene glycol; Sustained release

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