Abstract
Comparative studies on the application of cyclodextrins as sorbents for the separation of various isomers by two techniques, reversed-phase thin-layer chromatography and reversed-phase high-performance liquid chromatography were performed in parallel. The effects of α- or β-cyclodextrin concentration in the mobile phase solution on the k′ and RF values of o~, m~ and p~cresols, -nitrophenols, -nitroanilines, and 1- and 2-methylnaphthalenes and -nitronaphthalenes were investigated.With both techniques, substantial selectivity towards positional isomers (o~, m~ and p~substituted benzenes and 1- and 2-substituted naphthalenes) was observed, which resulted from inclusion in β-cyclodextrin cavities.Reversed-phase thin-layer chromatography was found to be a very useful, simple and fast procedure for preliminary studies of inclusion processes in the mobile phase solution and of their influence on Chromatographie separation.
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