Î³Aminobutyrate B Receptors in Central Amygdaloid and Medial Amygdaloid Nuclei of Amygdala Modulate Aggression in Male Rats

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doi:10.3844/amjnsp.2012.25.31

Abstract

One neurochemical system most consistently linked with aggression is the GABAergic system. The aim of the present investigation was to examine the effect of injection of baclofen (GABAB agonist) and CGP35348 (GABAB antagonist) in the Central Amygdaloid (CA) and Medial Amygdaloid (MA) nuclei of the amygdala on offensive aggression behavior in the animal model. Sixty six adult male rats weighing 180-200g were used. Cannula was implanted into each ac and or am nuclei of amygdala using stereotaxic method. Each animal received 100 electrical shocks every session. After electrical shock, another rat was placed in the electroshock chamber and the animals were observed for various aggressive behaviors. Data were analyzed by Students T test and one way ANOVA and Tukeys test as the post-hoc test. Significant level was considered to be p

Highlights

Aggressiveness is an ancestral behavior common to all animal species
The putative neural circuit of aggressive motivation identified with Functional Magnetic Resonance Imaging (FMRI) includes neural substrates contributing to emotional expression, emotional experience and the anterior thalamic nuclei that bridge the motor and cognitive components of aggressive response (Ricci et al, 2009)
Glutamate Decarboxylase proposed that both GABAA and GABAB receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is subject to the general inhibitory effect of GABAergic neurotransmission (Rudissaar et al, 2000)

Summary

INTRODUCTION

Aggressiveness is an ancestral behavior common to all animal species. Its neurophysiological mechanisms are similar in all vertebrates (Giammanco et al, 2005). Effect of CGP35348 injection in ac and am nuclei of amygdala on aggressive behavior: Figure 2A shows that after injection of CGP35348, 5 ng rat−1 in the ac the other rat F(1,12) = 6.5, p = 0.012 (0.3±0.01; 0.5±0.3; 0.3±0.02, 3.3±1.1) and bite- biting the other rat F(1,12) = 34.3, p = 0.000 (0.6±0.02; 1.0±0.5; 0.5±0.1; 4.8±2.1) nucleus of amygdala, several offensive aggression were significantly increased compared to the control and behaviors such as thrust movement of the whole sham groups. There were no significant changes in different after the injection of baclofen into these two animals receiving both doses with respect to the other nuclei It seems that baclofen might act on different offensive aggression behaviors; but CGP35348 (3 ng rat−1) significantly (p

DISCUSSION

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Methods