Abstract
Overexpression of the Na+/Ca2+ exchanger (NCX) in mammals is associated with arrhythmias in cardiac hypertrophy and failure. The function and regulation of NCX genes varies significantly among vertebrates likely reflecting differences in molecular structure. We have previously reported that β-adrenergic suppression of the Ca2+-efflux and -influx modes of amphibian cardiac NCX1.1 is associated with specific molecular motifs. In contrast, cardiac NCX of shark (Squalus acanthias) shows ‘bimodal’ adrenergic regulation with preferential suppression of the Ca2+-influx mode (Woo and Morad, PNAS 98:2023, 2001); and its sequence (DQ 068478) reveals two novel proline/alanine-rich AA-insertions.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
