Abstract
We showed that the mouse monoclonal antibodies directed against the beta isoform of heat shock protein 90 (Hsp90beta) bind specifically to Hsp90beta found on the surface of tumor and untransformed cells. After binding to membrane-associated Hsp90beta, antibodies actively dissociated into the culture medium and were internalized by cells. An immunoconjugate prepared on the basis of the Hsp90beta-specific antibody and the cytotoxic agent mertansine did not exhibit high cytotoxic activity against tumor cells in vitro. The injection of the Hsp90beta-specific antibody into mice did not influence the growth of primary tumor of epidermoid Lewis lung carcinoma but suppressed the metastasis of tumor in the lungs and increased the mean life span of mice. The results suggest a certain therapeutic potential of antibodies directed against Hsp90beta for tumor therapy.
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