Abstract
Detailed examinations were made on the protective action of adrenergic agents, barium agents, histamine agents, and compounds possessing chemical structure related to adrenaline against the irreversible suppressor of alkylation like dibenamine and irreversible antagonistic action of SH inhibitors like mercuric chloride, using the Magnus method employing isolated vascular series of a guinea pig. As shown in Fig. 2, action of 10-6M of dibenzamine against adrenergic receptor was selectively protected by adrenergic agents but the protection of barium chloride and histamine was non-selective. Dibenzamine in 10-4M concentration attacked the receptor of adrenaline, histamine, and barium chloride. There were no substances that showed protective action against the former two, but adrenergic agents and barium agents showed protection against the latter. The action of SH inhibitors like mercuric chloride against adrenergic receptor cannot be considered as specific, from the result of their protective action.
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