Abstract
In order to study the regional differences in the distribution of adrenergic receptors of the vas deferens, we measured the amounts of adrenergic alpha-1, alpha-2 and beta receptors in prostatic, intermediate, and epididymal portions of the dog vas deferens using radioligand binding techniques. Saturation experiments with 3H-prazosin, 3H-yohimbine, and 3H-dihydroxy-alprenolol demonstrated that there were significant amounts of adrenergic alpha-1, alpha-2, and beta receptors, respectively, in these three portions. alpha-1 receptors existed most densely in the whole vas deferens. The prostatic portion was found to have the largest amounts of alpha-1 and alpha-2 receptors among three portions studied. beta-Receptors were distributed most densely in the intermediate portion. alpha-1, alpha-2, and beta adrenergic receptors show different distribution patterns throughout the whole length of vas deferens.
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