Влияние вариантов С(-344)T гена альдостеронсинтазы CYP11B2 на уровень альдостерона сыворотки крови и риск развития фибрилляции предсердий у пациентов с метаболическим синдромом

Abstract

Background. Metabolic syndrome (MS) with atrial fibrillation (AF) is a significant medical and social problem. AF is a multifactorial disease with a genetic predisposition. Aldosterone contributes to the myocardial fibrosis and remodeling. So, investigation of influence of the aldosterone synthase CYP11B2 gene variants on serum aldosterone level and the risk of AF in patients with MS is of great interest. The purpose of the study was to assess serum aldosterone level as well as the frequency of cases of AF among MS patients with different С(-344)T variants of the CYP11B2 gene (rs1799998). Materials and methods. 201 MS patients (including 99 subjects with AF) and 267 controls were recruited to the study. All participants underwent serum aldosterone level measurement and С(-344)T variants detection with PCR followed by restriction analysis. Results. The frequency of TT genotype in controls was lower than in the MS whole group (p = 0.013) and lower than in the «MS without AF» group (p = 0.005). TT genotype was associated with increased risk of MS [OR = 2,00 (95%CI 1,23-3,26)] as well as with increased risk of «MS without AF» [OR = 1,66 (95%CI 1,11-2,48)]. Aldosterone level in the MS whole group was greater than in controls (p<0.001), and in the «MS with AF» group aldosterone level was greater than in the «MS without AF» group (p = 0.029). In controls, the T allele carriers showed greater aldosterone level compared to the CC genotype carriers (p = 0.015). Conclusion. We showed the association of (-344) Т allele of the aldosterone synthase CYP11B2 gene with the risk of MS, but not with the risk of AF.