Влияние ФНО-α, ИЛ-2, ИЛ-5, ИЛ-6 на сокращения мышц трахеи и бронхов крысы

Abstract

The article discusses the role of TNF-α, IL-2, IL-5, IL-6 in the contractile activity of the smooth muscles of the trachea and bronchi of rats. The studies were carried out on isolated preparations using electrical stimulation of postganglionic nerves (frequency - 30 stim / s, duration - 0.5 ms, amplitude - 20 V, duration of stimulation - 10 s). Two groups of animals were formed: a control group (received an intraperitoneal injection of saline) and an experimental group sensitized with ovalbumin (received an intraperitoneal injection of ovalbumin with its repeated administration after 14 days). Further, the assessment of the contraction of the muscles of the trachea and bronchi after repeated administration of ovalbumin and after perfusion with interleukin solutions was carried out. As a result of the study, it was found that TNF-α, IL-2, IL-5, IL-6 lead to a pronounced increase in the contractile responses of the smooth muscle of the trachea and bronchi both in the control group of animals and in the group of animals sensitized with ovalbumin. The greatest constrictor effect on muscle among the studied cytokines belongs to TNF-α and IL-6.