Влияние интерлейкинов на сокращения мышцы трахеи и бронхов крысы

Abstract

The article considers the role of IL-1β, IL-4, IL-8 and IL-13 in contractile activity of smooth muscles of trachea and bronchi. Studies were conducted on isolated preparations with using of electrical stimulation of the postganglionic nerves (frequency – 30 stimules/s, duration – 0,5 ms, amplitude – 20 V, duration of stimulation – 10 s.). Two groups of animals were formed: a control group (received an intraperitoneal injection of saline solution) and an experimental group with bronchial asthma (received an intraperitoneal injection of ovalbumin with its repeated administration after 14 days). Further, the tracheal and bronchi muscle contraction was evaluated after repeated ovalbumin administration and after perfusion with interleukin solutions. The study found that IL-4, IL-8 and IL-13 lead to a large increase in contractile responses of the smooth muscle of the trachea and bronchi both in the control group of animals and in the group of animals with ovalbumin-induced bronchial asthma. IL-1β leads to a relaxation effect on the tracheal and bronchi muscle in conditions of physiological norm and pathology, which can be considered as a compensatory mechanism that supports the function of external respiration.