돼지 써코바이러스 2형과 돼지 생식기 호흡기 증후군 바이러스 감염에 따른 림프절 병변에 대한 병리학적 연구

Abstract

Abstract : Porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) havebeen suspected to have immunosuppressive effects on pigs. To investigate the correlation between these virus infectionand the lesions of lymph nodes including sub-mandibular and inguinal lymph node, 44 pigs (PCV2 single, n = 14;PRRSV single, n = 10; PCV2/PRRSV, n = 14; negative control, n = 6) were examined by histopathology andimmunohistochemistry. Histopathologically, granulomatous lymphadenitis characterized by lymphoid depletion withhistiocytic cells infiltration was observed in PCV-2 single and PCV-2/PRRSV group. Immunohistochemically, therewere significant reduction of B and T lymphocytes in lymph nodes of these groups, while the number of macrophageswas increased. In only PRRSV infected group, germinal center hypertrophy and lymphoid necrosis were observed.Immunohistochemically, the number of CD3+ T lymphocytes was slightly increased. Severe lymphocytic depletionin PCV-2 infection-related lymph nodes might be associated with producing immunocompromised state in pig.Comparing with PCV-2 infected group, PRRSV produced minor effects on the changes in immune cell populationin the lymph nodes of pigs. PRRSV may increase susceptibility of the disease in pigs by disruption of the first defenselines in target organs, such as the alveolar macrophages in lungs.Keywords : immunohistochemistry, lymph node, pig, porcine circovirus type 2, porcine reproductive and respiratorysyndrome virus