Abstract
AIM. To evaluate the expression level of microRNA-143 in patients with atherogenic acute cardiovascular diseases. MATERIAL AND METHODS. A total of 133 patients with acute cardiovascular diseases of atherogenic etiology were examined. Group 1 included 81 patients diagnosed with ST-segment elevation myocardial infarction, and Group 2 included 52 patients diagnosed with atherothrombotic subtype of ischemic stroke in the carotid basin. The control group included 27 patients without a history of acute cardiovascular diseases. Upon hospitalization, all patients underwent examinations according to the standard of medical care for patients with stroke and acute coronary syndrome with ST-segment elevation. The degree of stenosis of coronary and internal carotid artery was determined by coronary angiography/duplex scanning. The laboratory diagnostics included an assessment of lipidogram parameters at the time of patent admission. The level of microRNA-143 (miR-143) in blood plasma was determined by real-time PCR. For statistical data processing, standard software packages SPSS Statistics, as well as Pandas and SciPy libraries, were used. RESULTS AND DISCUSSION. A higher level of LDL (p <0.0001) and a prevalence of occlusive atherosclerosis (p < 0.001, p < 0001) were revealed in patients of 1st group compared to the 2nd and control groups; severe stenosis was found in patients of both main groups (p <0.0001, p = 0.0007) compared to the control group with a predominance in patients of 1st group 1 (p = 0.001). Assessment of circulating miR-143 levels demonstrated a higher level of miR-143 (p <0.0001, p = 0.011) in patients of the main groups compared to the control group with a prevalence (p <0.0001) in patients of 1st group. The most significant correlation with the level of miR-143 was observed for LDL (r = 0.484) and the number of patients with severe atherosclerotic lesions of the coronary arteries (r = 0.454) in patients of 1st group, total cholesterol (r = 0.445), presence of diabetes mellitus (r = 0.418) and borderline atherosclerotic stenosis (r = 0.415) of the internal carotid artery - in patients of 2nd group. CONCLUSION. The results of the study allow us to consider the level of miR-143 as one of the important regulators of the process of atherogenesis. The obtained results indicate the necessity to conduct multicenter studies with a larger sample size to determine the potential value of miR-143 as a biomarker of severity and course of acute cardiovascular diseases associated with stenosis of major arteries.
Published Version
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