Abstract
In male C3H-A mice the effect of prolonged (44 weeks) thyroxine hyper- and propylthiourаcyl hypothyroidism on the hormonal status and content of monoamines and their metabolites in the symmetric parts of the forebrain was studied. The level of hormones in the blood serum was determined by enzyme-linked immunosorbent analysis and the content of monoamines (MA) and their metabolites in the brain was determined by HPLC. Experimental hyper- and hypothyroidism did not cause opposite changes in the MA content. So, with any change in thyroid status in the hippocampus and tuberculum olfactorium the level of serotonin (5-HT) increased. At the same time the content of norepinephrine (NA) in the striatum decreased and in the tuberculum olfactorium increased. The level of dopamine (DA) in the striatum and tuberculum olfactorium in animals of both experimental groups increased, however, in hypothyroid mice this effect was observed bilaterally and in hyperthyroid mice it was unilateral; only in the left striatum and right tuberculum olfactorium. In addition to these changes in experimental hyperthyroidism there was a decrease in the level of DA in the cerebral cortex, and in hypothyroidism, an increase in 5-HT in the right striatum and in the right cortex. Most characteristics of monoaminergic systems did not correlate with the content of thyroxin (T4) but correlated with the levels of thyrotropin (TSH) and prolactin (PL) in the blood. At the same time no correlation was found between the content of these hormones and T4, although TSH and PL levels correlated with each other. It can be assumed that the leading role in the mechanisms of the influence of a prolonged change in thyroid status on the monoaminergic systems of the brain is mediated not by T4 but by TSH.
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