Abstract
In Asian'flu epidemic, 81 viruses isolated from 157 cases at Gunma prefecture and serological tests were performed with paired sera.The virus donors showed significant rise in CF and HI antibody titers with paired sera and there was no difference between CF and HI tests for the detection of antibody responses.Most of the sera from cases in 1st wave showed remarkable titer rises with P strain but not with Q strain. In 2nd wave, however, some cases indicated demonstrable titers against both kinds of virus.Hemagglutination-inhibition tests were performed with paired sera from 75 patients in previous influenza outbreaks and none of these sera showed detectable antibody against the Asian'flu virus. Antibody patterns in pooled sera from the Asian patients were determined with prototype strains. Serum pools from children and young adults showed significant rises in antibody titer against Asian and FM1 viruses. The group from 30 to 40 years of age showed such rises against Asian and PR8 viruses, and antibody rises to Asian and Swine influenza were demonstrated in those above 40 year of age.It is clear that a principle labelled “the doctrin of original antigenic sin” has been demonstrated also by the data following infection of Asian'flu virus.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call