Abstract
A new high-performance liquid chromatographic method with ultraviolet detection has been used to determine the levels of new cardiotropic drug protecor in the blood of animals (rabbits and beagle dogs). The parameters of protecor pharmacokinetics and bioavailability upon peroral administration of protector tablets have been determined. Rabbits showed effective absorption of the drug upon peroral administration in a single dose (100 mg/kg), with a peak concentration in the plasma (Cmax = 41 μg/ml) reached within Tmax = 3 h and was followed by rapid removal of the drug from the organism at a half-elimination time of T1/2β = 1.71 h. Peroral administration of protecor in a single dose (50 mg/kg) in beagle dogs was characterized by Cmax = 34.6 mg/ml, Tmax = 3 h, and T1/2β = 0.75 h. The bioavailability of protecor upon peroral administration was estimated at 90% (rabbits) and 80.7% (beagle dogs).
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