Abstract
The experimental pharmacokinetics of the new antioxidant agents fenozan acid and fenoxan (potassium salt of fenozan acid) administered in a dose of 100 mg/kg were studied in rabbits by monitoring the concentration profiles of drugs in the blood using the gas-liquid chromatography (GC). Upon peroral administration, both fenozan acid and fenoxan are rapidly absorbed into the blood, their maximum concentrations peaking within 12 min after administration. A change in the fenozan acid concentration in the blood plasma upon peroral administration was described by the one-compartment pharmacokinetic model, and that upon the intravenous injection, by a two-compartment model. The pharmacokinetic parameters characterizing the distribution and elimination of fenozan acid and fenoxan were close for both peroral administration and intravenous injections. Fenozan acid was slowly eliminated from the rabbit organism, the mean retention times being 11.3 and 11.8 h, and the half-elimination times being 8.28 h and 7.68 h (i.v. versus p.o., respectively). The stationary distribution volume for fenozan acid was 20.8 and 37.5 liter/kg (i.v. versus p.o., respectively), which is indicative of the possibility of intracell penetration. A relatively low value of the bioavailability of fenozan acid upon peroral administration ( F = 57 %) is evidence of a presystemic metabolism of this drug.
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