Abstract
Intravitreal injections (IVI) are widely used in current clinical ophthalmology as a method of drug delivery. One of the adverse events of the procedure is translocation of silicone oil droplets (SOD) into the vitreous body, which is a component of single-use syringes. Purpose. To evaluate the frequency of detection of SOD in the vitreous of patients who received multiple IVI of drug solutions; to evaluate the relationship of the frequency of SOD detection on the number of IVI performed. Material and methods. A single-center retrospective cohort study was performed. The study group consisted of 86 eyes of 85 patients who received an average of 13.2 IVI. SOD in the vitreous was detected by biomicroscopy in 57 eyes (66.28 %), by ultrasonography in 76 (88.37 %) cases. The results between methods matched in 73.26 % of observations. The hypothesis put forward in the course of the study about an increase in the probability of SOD getting into the vitreous body with an increase in the number of IVI was confirmed statistically. Conclusion. Translocation of SOD into the vitreous in IVI is a problem that is relevant for current ophthalmology and requires further study and solution. Among the ways to solve the problem are the registration of drugs for IVI in prefilled syringes, as well as the development of syringe models that take into account the specifics of use in ophthalmology. Keywords: intravitreal injection, silicone oil droplets, syringe, biomicroscopy, ultrasonography.
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