Ефективність бактеріальних лізатів у комплексній терапії дітей раннього віку з вірусними крупами

Abstract

The paper presents the results of studying the features of the cytokine status and indicators of local immunity of children with acute respiratory viral infection, proceeding with the manifestations of the syndrome of croup, and an evaluation of the efficiency of using bacterial lysates in a multimodality treatment of patients. It has been corroborated that edematous and hypersecretory variants of croup proceed against a background of a considerable intensification of a systemic inflammatory response and a decrease of the factors of local immunity; whereas the spasmodic variant – develops against a background of the physiologic level of cytokines and an increase of the factors of local immunity in the acute period of the disease. The use of bacterial lysates in multimodality therapy of patients with the edematous variant of the syndrome of croup is accompanied with an insignificant decrease in the level of cytokines, whereas with the hypersecretory variant the content of cytokines decreases almost 4-5 times. Against a background of the intake of bacterial lysates with the edematous variant the activity and content of the factors of local immunity rises somewhat, but their level remains lower than the indicators of the control group, with the hypersecretory variant their level reaches the indicators of healthy children. The results of the research enable to recommend bacterial lysates to be used in multimodality therapy of patients afflicted with the hypersecretory variant of croup that will promote a more rapid normalization of the systemic inflammatory reaction and a stimulation of the production and activation of the factors of local immunity in sick children.