Фактор активації системної запальної відповіді як предиктор негативних наслідків парвовірусної інфекції у різних триместрах вагітності

Abstract

Parvovirus infection during pregnancy can lead to abortion, intrauterine infections of the fetus with developmental defects. Subclinical forms of parvovirus infection prevail over manifestation, therefore the study of the activation factors of the systemic inflammatory response is shown as an adjunct to the diagnosis of subclinical infection among pregnant women with preterm or preterm labor with the presence of clinical complications. Immunological studies that included the determination of the pro-inflammatory activation factor were investigated. The cytokine status and C-reactive protein as a marker of inflammation in 129 pregnant women infected with parvovirus infection in different periods of pregnancy were studied. The results were analyzed by dividing women into three groups by trimesters and by the presence of clinical complications of viral infection. Control for comparison was women with physiological pregnancy in the corresponding trimester. An analysis of the data on the content of cytokines in serum of pregnant women revealed a change in the ratio of pro- (IL-8, IL-2 and FNP-) and anti-inflammatory (IL-10) cytokines, which may be indicative of a systemic immune response to B19 infection during various pregnancy and pregnancy. The results of the study of C-reactive protein (hsCRP) indicate a moderate increase in its concentration in the blood of patients with parvovirus infection, which is associated with minor tissue damage. Of the 129 pregnant women with B19 infection, 57 (44.2%) women had elevated CRP levels (20% higher than the control level for the respective trimester). Key words: parvovirus infection, pregnancy, cytokines, C-reactive protein, clinical complications of pregnancy.