ｉｎ ｖｉｔｒｏにおけるアルブミン製剤の薬物結合能の検討

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This study discusses the possibility that human serum albumin (HSA) preparation has equal binding efficiency with drug to normal serum albumin. The binding percentage with theophylline (TH) in vitro was 61-64% in normal serum albumin, 32% in HSA preparation, and 65% in dialyskl HSA preparation.This suggests that the fall of the binding percentage with TH in HSA preparation results not from the heat treatment but from the stabilizers.In addition, the influence of the change of pH value on the binding efficiency was equal in both normal albumin and HSA preparation, which suggests that the binding state of HSA preparation with TH is similar to that of normal serum albumin.