マウス口底膿ようモデルを用いた歯性感染症起炎菌の病原性の検討 Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｃｏｎｓｔｅｌｌａｔｕｓ，Ｆｕｓｏｂａｃｔｅｒｉｕｍ ｎｕｃｌｅａｔｕｍの膿よう形成能について

Abstract

The oral floor abscess model in mice was newly created by inoculating the oral floor with pathogens of odontogenic infection.Two pathogens of odontogenic infection, Streptococcus constellatus and Fusobacterium nucleatum, were investigated with respect to virulence, including synergy in mixed infection, on the basis of the rate of abscess formation, mortality rate, and number of bacteria in theabscess, as assessed with this model. Abscess formation was found in single infection with S. constellatus or F. nucleatum. Synergy of virulence was found between S. constellatus and F. nucleatum.The results of the present study suggest that synergy contributes to the onset and worsening of odontogenic infections. Moreover, these results support the clinical microbial finding that odontogenic infections are usually polymicrobial. In conculusion, this oral abscess model might be very useful in the study of odontogenic infections.