マウス口底膿ようモデルを用いての歯性感染症起炎菌の病原性の検討 病原性の比較

Abstract

In present study, the pathogenicity of Streptococcus constellatus, Peptostreptococcus micros, Prevotella intermedia, and Fusobacterium nucleatum, which are implicated in odontogenic infection, was determined using an oral floor abscess model in mice. The potential to kill mice, the ability to form an abscess, and the lesion type were used as indices of pathogenicity. The results showed that F. nucleatum was more pathogenic than the other pathogens. It appeared that P. micros and P. intermedia acted aggressively and destructively when the mice were challenged with a sufficient number of these pathogens. Moreover, it appeared that P. intermedia caused a spreading inflammatory lesion that spread to the surrounding tissue via spaces in the oral floor tissue. The present study suggests that pathogens responsible for odontogenic infection differ with respect to pathogenicity.