Abstract
Currently, topical hypotensive therapy is the main means of glaucoma treatment. Frequently, the achievement of the target level of ocular pressure is possible only with the simultaneous use of several topical hypotensive drugs. A complex instillation regimen and a high incidence of adverse effects contribute to compliance reduction. All this leads to therapy efficacy decrease and the disease progression. The use of fixed combinations can simplify the instillation regimen during the day and reduce the incidence of adverse effects. The use of fixed combinations of prostaglandin analogues and timolol maleate allows us to achieve a more pronounced hypotensive effect with a single instillation of the drug during the day. In this review, we will try to summarize current data on the fixed combination of latanoprost and timolol maleate (FCLT), its pharmacological effects and hypotensive effectiveness, compared to other antihypertensive drugs and their combinations.
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