Abstract
The oral glucose tolerance test (OGTT) is used in the screening of gestational diabetes, in diagnosis of type 2 diabetes in conjunction with fasting blood glucose and glycated hemoglobin. The aim of this study was to examine the incidence and risk factors of adverse effects of OGTT in patients who underwent bariatric surgery, in addition to proposing standardization for ordering the OGTT in these patients. This study assessed the incidence of adverse effects in 128 post-bariatric surgery patients who underwent the OGTT. Descriptive and logistic regression analysis were performed, the dependent variables were defined as the presence of signs (tremor, profuse sweating, tachycardia), symptoms (nausea, diarrhea, dizziness, weakness), and hypoglycemia (blood glucose ≤ 50 mg/dL). One hundred and seventeen participants (91.4%) were female; 38 (29.7%) participants were pregnant. High incidence (64.8%) of adverse effects was observed: nausea (38.4%), dizziness (30.5%), weakness (25.8%), diarrhea (23.4%), hypoglycemia (14.8%), tachycardia (14.1%), tremor (13.3%), profuse sweating (12.5%) and one case of severe hypoglycemia (24 mg/dL). The presence of signs was associated with hypoglycemia (OR = 8.1, CI 95% 2.6-25.1). The arterial hypertension persisted as a risk factor for the incidence of signs (OR = 3.6, CI 95% 1.2-11.3). Fasting glucose below 75 mg/dL increased the risk of hypoglycemia during the test (OR = 9.5, CI 95% 2.6-35.1). In this study, high incidence of adverse effects during the OGTT was observed in post-bariatric surgery patients. If these results are confirmed by further studies, the indication and regulation of the OGTT procedure must be reviewed for these patients.
Highlights
The oral glucose tolerance test (OGTT) is a timehonored test, which has been ordered since 1922 [1] with multiple indications in clinical practice
The present study examines the incidence of adverse effects in 128 patients who underwent bariatric surgery (Roux-en-Y gastric bypass) and were referred for an OGTT at a clinical laboratory with ISO 9001:2008 certification and accreditation by the PALC/SBPC (Brazilian Society of Clinical Pathology) and DICQ/ SBAC (Brazilian Society of Clinical Analyses) in Belo Horizonte, Brazil, from January 2010 to December 2011
The present study warns of the high incidence (64.8%) of adverse effects and hypoglycemia (14.8%) during the OGTT in post-bariatric surgery patients
Summary
The oral glucose tolerance test (OGTT) is a timehonored test, which has been ordered since 1922 [1] with multiple indications in clinical practice. The objective of the present study was to investigate the incidence and risk factors for adverse effects to OGTT in post-bariatric surgery patients.
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