Abstract
Together with a new series of imidazoles [2,1-b]benzthiazoles connected with various heterocyclic scaffolds, a novel Mannich base link with the drug Cefixime was also developed. In order to create the isoxazole ring, a Mannich base with a terminal methyl group was condensed with various substituted aromatic aldehydes, resulting in new chalcones. These chalcones were then brought closer together with hydroxylamine hydrochloride to produce new isoxazole derivatives. All compounds were identified by the spectra of carbon-13 (C13) nuclear magnetic resonance, proton nuclear magnetic resonance, and Fourier transform infrared spectroscopy. The effectiveness of certain novel compounds as anticorrosion agents was demonstrated by others.
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