Abstract
There is a rather high prevalence of oncological complications in the world, in particular, the development of osteonecrosis while using bisphosphonate drugs. There are several reasons for their development. We had a task to evaluate microcirculation in the development of medication-related osteonecrosis in an experimental model of rats. We administered the Zoledronic acid for 3 weeks to rats, and studied the line rate of blood flow using laser and high-frequency Doppler ultrasound in the periodontal area of an extracted tooth in rats with application of vasoactive substance Acetylcholine 3% for 1 min. The changes in the bone structure were assessed using computer tomography of the head of the examined rats. The results revealed a quick decrease in microcirculation against the background of the use of Zoledronic acid for 3 weeks. A decrease in blood flow in the mucous membrane and bone tissue was detected. The obtained data correlated with different hypotheses of the effect of bisphosphonates on the blood flow. Zoledronic acid causes a statistically significant impairment of the periosteal blood flow, the mucous membrane due to a complex of disorders, which includes the cellular component (impaired endothelium-dependent vasodilation of the mucous membrane vessels) and the reduction of microcirculation in the mucous membrane and bone tissue.
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