Патоморфологічна характеристика коронавірусної інфекції в собак

Abstract

The results of the study of the morphological features of pathological processes in organs and tissues of dogs with coronavirus infection. The study of cadavers (n = 3) dogs of different breeds and sex between the ages of 2 to 6 months, who died with diarrheal syndrome. Presence of coronavirus, without other assiociants, in these cases had previously been confirmed in the polymerase chain reaction analysis of fecal samples. At this stage, the main method of our study was mortem autopsy. At autopsy, which was carried out in partial evisceration, recorded and described the macroscopic changes identified in various tissues and organs of dead dogs and selected pathological material for subsequent histological examination. It is shown that the most pronounced lesions and typical change in all dead dogs fixed contact in the small intestine (jejunum and to the ileum) and the regional lymph nodes to it, as well as in the spleen. It is shown that the morphological manifestations of coronavirus infection in dogs following features are on the macroscopic level: the presence of exudative inflammation in the small intestine in the form serous-fibrinous jejuno-ileitis; hyperplasia and serous-hemorrhagic lymphadenitis mesenteric lymph nodes; multiple foci of hemorrhage of different character (spotted and striped) in the parenchyma of the spleen and serous membrane of the small intestine; dilatation of the right ventricle of the heart; cachexy and dehydration due to diarrheal syndrome. Also, non-specific, but constant morphological features, which arose as a result of circulatory disorders and heart failure were: passive venous congestion of the liver, kidney and pulmonary edema; degenerative processes in the liver. In one case, we identified morphological features characteristic of serous-inflammatory swelling of the pancreas and pathological changes in the myocardium that are typical of concentric hypertrophy of left ventricular heart. These pathological processes can be considered a complication that developed as a result of the underlying disease.