Abstract
맥문동, 차가버섯, 감초, 보기보혈(백출, 백복령, 당귀, 숙지황, 천궁, 작약)의 한방약재에 ginsenoside Rg3가 강화된 흑삼을 첨가한 토너와 로션을 제조하여 주름개선 효과를 평가하였다. 평균연령 42.5세의 한국인 중년여성 6명을 대상으로 토너사용 후 로션사용으로 매일 2회씩(아침, 저녁) 4주간 연속 사용하도록 한 다음, 실험 4주 후에 눈가 주름의 모사판을 제작하여 영상 분석하였다. 또한 연구책임자가 시료의 피부 안전성을 관찰하기 위해 육안 검사도 함께 수행하였다. 눈꼬리 주름 모사판 영상분석 결과, 토너와 로션 사용 4주 후 주름 R1은 <TEX>$3.15{\pm}0.35$</TEX>에서 <TEX>$2.28{\pm}0.22$</TEX>, R2는 <TEX>$2.99{\pm}0.37$</TEX>에서 <TEX>$2.13{\pm}0.21$</TEX>, R3는 <TEX>$2.09{\pm}0.31$</TEX>에서 <TEX>$1.56{\pm}0.18$</TEX>, R4는<TEX>$0.37{\pm}0.05$</TEX>에서 <TEX>$0.29{\pm}0.03$</TEX>, R5는 <TEX>$0.89{\pm}0.1$</TEX>에서 <TEX>$0.75{\pm}0.06$</TEX>로 유의하게 감소하여(P<0.05), 본 시료는 주름개선에 효과 있는 것으로 확인되었다. This study evaluated anti-wrinkle effect using toner and lotion containing ginsenoside Rg3 enriched black ginseng in oriental medicine like Liriope platy phyllla, Inonotus obliquus, Glycyrrhiza glabra and nourishing of the blood and energy(Atractylodes japonica, Poria cocos Wolf, Angelica gigas, Rehmanniae Radix Preparata, Cnidii Rhizoma, Paeonia lactiflora). 6 female adults on average at the age of 42.5 applied lotion after toner under the normal conditions of use on the face including crow's feed area, twice a day (in the morning and evening) for 4weeks. After 4 weeks, the replica of eye wrinkle was made and analyzed the image. The result was decreased in R1(<TEX>$3.15{\pm}0.35$</TEX> to <TEX>$2.28{\pm}0.22$</TEX>), R2(<TEX>$2.99{\pm}0.37$</TEX> to <TEX>$2.13{\pm}0.21$</TEX>), R3(<TEX>$2.09{\pm}0.31$</TEX> to <TEX>$1.56{\pm}0.18$</TEX>), R4(<TEX>$0.37{\pm}0.05$</TEX> to <TEX>$0.29{\pm}0.03$</TEX>), and R5(<TEX>$0.89{\pm}0.1$</TEX> to <TEX>$0.75{\pm}0.06$</TEX>)(P<0.05). Therefore, oriental medicine cosmetics containing black ginseng may play a role anti-wrinkle.
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