アルギニン負荷試験による小児の血糖，血清インスリンおよび血しょうグルカゴンの動態 Ｉ 健康小児について

Abstract

The changes in blood glucose (BG) levels, serum immunoreactive insulin (IRI) levels and plasma immunoreactive glucagon (IRG) levels were studied during arginine tolerance tests in 52 healthy infants/children. The subjects were divided into three age groups: group I-A (1 month to 3 years old), group I-B (4 to 9 years) and group I-C (10 to 15years).The results obtained were as follows.In all age groups, the BG levels (Mean±SEM) were found to reach maximum at 15 min. after the arginine administration (group I-A; 114±5.4mg/dl, group I-B; 105.1±1.7mg/dl, group I-C; 108.5±3.1mg/dl, respectively). These responses were not age-dependent.The basal levels of IRI (Mean±SEM) were significantly higher in older children than in younger ones (group I-A; 4.2±0.7. μU/ml, group I-B; 5.3±0.8. μU/ml, group I-C; 8.4±1.1 μU/ml, respectively). The serum IRI levels (Mean±SEM) rose to the maximun level. E at 30 min. after the arginine administration and the responses to arginine were significantly greater in older children than in younger ones (group I-A; 14.2±3.4. μU/ml, group I-B; 25.6±2.2. μU/ ml, group I-C; 60.5±11.0. μU/ml, respectively).In contrast to the IRI responses, the basal IRG levels (Mean±SEM) tended to be comparatively higher in younger children than in older ones (group I-A; 107.1±12.7. Eg/ml, group I-B; 95.8±10.7. Eg/ml, group I-C; 72.8±9.3. Eg/ml, respectively), and the maximum levels of IRG (Mean±SEM) at 30min. after the arginine administration were observed to be significantly higher in younger children than in older ones (group I-A; 449.6±66.1. Eg/ml, group I-B; 345.0±20.7. Eg/ml, group I-C; 275.8±21.7. E g/ml, respectively).