Особливості гестаційної динаміки вмісту токсичних мікроелементів у сироватці крові та еритроцитах жінок різного репродуктивного віку, що народжують уперше

Abstract

The objective: to study features of gestational dynamics of levels of toxic elements in serum and erythrocytes of women of all reproductive age give birth first time. Patients and methods. Detection of toxic ME conducted in serum and erythrocytes of pregnant women of early, middle and high reproductive age who gave birth for the first time. Reproductive age of pregnant women was 16.33±0.21 years, 24.67±0.37 and 36.14±0.77 years. The study was conducted in the first, second and third trimesters of pregnancy at 10.26±0.34, 23.23±0.51 and 36.08±0.59 weeks of gestation. Content of ME (chromium, nickel, lead, cadmium) in biological substrates was determined by atomic absorption spectrophotometer C-115 MI equipped computer console for automatic calculation of ME content production Selmi (Ukraine). Results. In pregnant women of middle reproductive age changing of contents of toxic microelements were different - serum level of nickel and chromium significantly decreased, its associated with a significant deterioration of the placental barrier against them in the third trimester of pregnancy and transporting them to the fetus. Increased serum lead opposite rising due to the ability of the placenta blocking its active transport. In the blood of pregnant women of middle reproductive age was detected extremely toxic cadmium, while its content in serum and erythrocytes has been steady throughout the pregnancy. Comparative analysis of contents and balance of microelements in serum and erythrocytes in women giving birth for the first time, during pregnancy indicates a more unfavorable structure of the contents of toxic elements in women of early reproductive age compared to the women of middle reproductive age. Until the end of the third trimester of pregnancy there is an increasing of content of toxic nickel and lead in red blood cells and in serum – cadmium. In women of older reproductive age compared to the women of middle reproductive observed trend of increasing toxic nickel and cadmium in blood serum and erythrocytes. Conclusions. The perspective is to determine the role of the placenta in protecting the fetus from exposure of toxic elements and its functions – transport, barrier, depositing on toxic trace elements during the gestational process. Key words: toxic elements, pregnant women, reproductive age, first birth.