Abstract
The body mass index (BMI) is one of the key and at the same time simple and significant indicators of the state of the human body. Both large and small quantities of BMI is associated with high morbidity. The aim of the study was to analyze microecological disorders of intestinal biocenosis in children of different ages using the value of BMI as the criterion of comparison. We researched scatological material from 158 children and adolescents aged from 5 to 17 years (77 boys and 81 girls). The material was divided into three comparison groups depending on the BMI value: group 1 - body mass deficit (n = 34); group 2 - patients having body mass excess (n = 37); group 3 - with normal body mass (n = 87). It has been shown that more than 80 % of children with different BMI value were recorded to have dysbiotic disturbances of the intestinal microbiota of degrees 1 and 2. However, in the group of children with normal body mass, frequency of detection of intestinal dysbiosis was significantly lower; in the group of children with underweight dysbiotic disorders were found significantly more often than in overweight and obese children (p < 0.05). In children with body mass deficit we observed not only increasing concentration of opportunistic pathogenic bacteria, but also an increased occurrence of representative of Enterobacteriаceaе. family. 58.8 % of cases had two- and three-component associations of opportunistic pathogenic bacteria, which is an indication the expressed violations of the intestine microbiocenosis formation. The data obtained show that,you can use BMI, an important criterion reflecting the severity of the disease, in the assessment of intestinal microflora in combination with other studies.
Highlights
The body mass index (BMI) is one of the key and at the same time simple and significant indicators of the state of the human body. Both large and small quantities of BMI is associated with high morbidity
The aim of the study was to analyze microecological disorders of intestinal biocenosis in children of different ages using the value of BMI as the criterion of comparison
The material was divided into three comparison groups depending on the BMI value: group 1 – body mass deficit (n = 34); group 2 – patients having body mass excess (n = 37); group 3 – with normal body mass (n = 87)
Summary
Материалом для исследования послужили копропробы от 158 детей и подростков в возрасте от 5 до 17 лет (77 мальчиков и 81 девочка), обратившихся в гастроэнтерологический центр ФГБНУ НЦ ПЗСРЧ. Бактериологическое исследование фекалий и оценку количественного и качественного состава кишечной микрофлоры толстой кишки проводили в соответствии с Отраслевым стандартом «Протокол ведения больных. Для выделения и идентификации микроорганизмов использовали селективные питательные среды производства ФГУН Государственный научный центр прикладной микробиологии (Оболенск, Россия), НИЦФ (Санкт-Петербург, Россия), Himedia (India), коммерческие идентификационные тест-системы производства «PLIVA-Lachema Diagnostika» (Чехия), Himedia (Индия). Исследование проводилось с соблюдением этических принципов, предъявляемых Хельсинской декларацией Всемирной медицинской ассоциации (World Medical Association Declaration of Helsinki, 1964, 2013), и выполнено с информированного согласия родителей пациентов. Статистическая обработка данных произведена при помощи лицензионных прикладных программ «MS Excel 2007 for Windows 7». Статистическую значимость определяли с помощью корреляционного анализа (метод Пирсона), при р ≤ 0,05 различия считали статистически значимыми
Published Version (Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have