СРОКИ ФОРМИРОВАНИЯ ИММУНИТЕТА У ОВЕЦ, ВАКЦИНИРОВАННЫХ АССОЦИИРОВАННОЙ ВАКЦИНОЙ ПРОТИВ ЧУМЫ МЕЛКИХ ЖВАЧНЫХ ЖИВОТНЫХ И ОСПЫ ОВЕЦ

Abstract

The article presents the results of studies to determine the timing of the onset of immunity in sheep vaccinated with the associated vaccine against peste des petits ruminants (PPR) and sheep pox (SP). The timing of the onset of immunity in vaccinated animals against PPR and SP was evaluated by serum neutralization test (SNT) and by testing the withstood of vaccinated sheep to challenge infection with virulent strain "A" of SP virus. Protective tiers of virus neutralizing antibodies (VNA) to the PPRV virus were formed on 14 days with an average value of 2.8 log2 and reached up to 4.7 log2 on 21 days after vaccination, while immunity against the OO virus was formed on 7 days after vaccination with an average VNA titer of 1.8 log2, which increased to 4.3 log2 on 21 days after vaccination. All immunized sheep’s showed resistance to the virulent SP virus until the end of the experiment. Therefore, the experimental data obtained by us indicate a high degree of protection of animals immunized with the associated vaccine against PPR and SP, starting from day 7 from the SP virus and from day 14 from the PPR virus. Key words: combined vaccine, peste des petits ruminants, sheep pox, immunity.