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Abstract
Objective. To study the effects of N-acetylcysteine (NAC), dexamethasone and their combination on the parameters of lipid peroxidation (LPO) and antioxidant defense (AOD) in the posterior segment tissues of rabbit eye under experimental immunogenic uveitis (EIU). Material and methods. The experimental study was carried out on 45 rabbits (90 eyes), 5 of which were intact. The animals with EIU were divided into 8 groups (5 animals each) in which daily intramuscular injections of placebo, NAC, dexamethasone or a combination of NAC and dexamethasone were used for 3 or 7 days. Subsequently the content of LPO products, concentration of reduced glutathione, oxidized glutathione and their ratios, activity of superoxide dismutase and catalase enzymes as well as the total antioxidant activity were determined in the posterior segment tissues of the rabbit eyes. Results. Application of NAC led to a significant decrease in the concentration of LPO products, as well as a significant elevation of AOD parameters. Dexamethasone had a negative effect on the glutathione system in the tissues of the eye. The combined use of NAC and dexamethasone revealed the synergism of their pharmacological action and made it possible to increase the overall antioxidant potential of the therapy. Conclusion. NAC parenteral administration showed a pronounced antioxidant effect. Combination therapy with NAC and dexamethasone significantly increased effectiveness of the treatment. The data obtained allows recommending NAC administration as part of the complex therapy of uveitis.
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