Оценка эффективности и безопасности фиксированной комбинации амлодипина и периндоприла (препарат Престанс) у больных артериальной гипертензией во время летней жары

Abstract

Relevance. Impact of the drugs on adaptation to the heat wave of abnormal temperature has been one of the most important practical medicine questions in recent years. One of the points at issue is safety calcium channel antagonists and ACE inhibitors treatment during abnormal heat. The aim of the study is to investigate the efficacy and safety of perindopril arginine (drug Prestance - Servier Industries, Ltd.) and amlodipine fixed combination in arterial hypertension (AH) patients during the summer heat and the summer heat influence on the adaptation mechanisms to abnormally high temperatures.Materials and methods. The study enrolled 165 patients with stages 1 and 2 AH: 69 patients with average risk and 91 patients with high andvery-highrisk of cardiovascular complications. There were 69 men and 96 women in the study, living in Moscow city, in the Moscow and in the Ivanovo Regions. All patients were measuring office BP, biochemical blood assay and hematocrit and were running questionnaire survey: visual analogue scale (VAS), Morisky-Green test and questionnaire for the patients who were exposed to heat. Pulse ware velocity was measured in 30 patients. The first visit was done in the first half of June 2013, the second visit - during the heat (July 2013), the third one in September 2013. Results. In the course of the study systolic (SBP) and diastolic BP (DBP) were reduced (р<0,00001) and the SBP and DBP target level reached 73,9% (41,9% - durig the second visit). We observed the increase of VAS and Morisky-Green test scores from 2,24±1,43 (Ме 2,0) to 3,26±0,91 (the 2ed visit) and to 3,49±0,91 (Ме 4,0) (3ed visit), hyperkalemia (р=0,0056), hyponatremia (р=0,00042), hypocreatinemia (р=0,018), hypocholesterolemia (р<0,00001), hypotrigliceridemia (р=0,027), hypoglucosemia (р=0,0035). We noted pulse ware velocity and hematocrit reduction (the 3ed visit). Conclusion. Therapy of Prestance was effective, safe and well tolerated by AH patients during the summer heat without any sings of hypotension and electrolyte imbalance which were attributed to bodyheat. Improvement of adaptive response in the human body was associated with effective arterial elastance and reduction in blood viscosity.