실질적 동등성에 근거한 유전자변형 벼의 안전성 평가

Abstract

Genetically modified crops must undergo safety evaluation approval before commercial use, ensuring substantial equivalence compared to conventional crops. Safety assessment based on 'substantial equivalence' involves a stepwise approach, comparing GM crops with their non-GM counterparts, examining statistical differences or equivalence within the natural variability range for the desired attributes. For instance, if statistically significant differences are observed in safety test items between GM and control crops, additional analysis compares them to the commercially available varieties to determine inclusion within their compositional range. Further analysis involves biological or toxicological assessments if difference between GM crops and others are identified. Using data from insect-resistant genetically modified rice and its non-GM counterpart, available in the Rural Development Administration's crop component database, we applied statistical methods for substantial equivalence assessment. The substantial equivalence assessment of GM crops covers various evaluation aspects, including toxicological, allergenic, and nutritional attributes. In this study, statistical analysis was performed on rice's nutritional component data, integrating the results with theoretical contents.