Исследование зависимости физико-химических свойств флуоресцентных гибридных полимерных носителей от условий гидротермального синтеза

Abstract

Currently, the search for new types of carriers for low-molecular weight substances, as well as the development of optimal methods for the effective encapsulation of these substances are important tasks of modern chemistry and pharmacology. However, there are still limitations in this area, among which one of the most significant is the lack of the optimal carrier capable of stably retaining a low-molecular weight substance. The work presents hybrid polymer structures obtained by in situ hydrothermal synthesis as an effective candidate for these purposes. The fluorescent dye rhodamine B has been used as a model low-molecular weight substance for encapsulation into the structures. The resulting hybrid polymer structures demonstrated good stability when stored in an aqueous environment for 336 h with the release of the low-molecular weight dye rhodamine B no more than 2%. In addition, the influence of the conditions for obtaining hybrid carriers (including the composition of the carriers (thickness of the polymer shell and the presence of a calcium carbonate core) and synthesis temperature) on their physical-chemical characteristics has been studied. Thus, the optimal approach for obtaining fluorescent hybrid polymer carriers with a set of desired properties has been revealed. In particular, it has been shown that the optimal production conditions are hydrothermal synthesis temperature of 180 °C and the absence of CaCO 3 core inside the polyelectrolyte shell which allow us to obtain a stable hybrid polymer carrier with bright fluorescence. The results presented in this study can be used to create functional platforms and systems with tunable fluorescent properties and the ability to deliver low-molecular weight substances.